THE INFLUENCE OF A NEW RUTIN
DERIVATIVE ON HOMOCYSTEINE,
CHOLESTEROL AND TOTAL ANTIOXIDATIVE
STATUS IN EXPERIMENTAL DIABETES IN RAT
ELENA ALBU 1, DAN LUPAŞCU2*, CRISTIANA FILIP3, IRINA M.
JABA1, NINA ZAMOSTEANU3
1Department of Pharmacology, „Grigore T. Popa” University of
Medicine and Pharmacy, Str.Universitatii nr.16, 700115 Iasi, Romania.
2Department of Pharmaceutical Chemistry, „Grigore T. Popa”
University of Medicine and Pharmacy, Str.Universitatii nr.16, 700115
Iasi, Romania.
3Department of Biochemistry, „Grigore T. Popa” University of Medicine
and Pharmacy, Str.Universitatii nr.16, 700115 Iasi, Romania.
*corresponding author: danlup69@yahoo.com
Download Full Article

Abstract:

Diabetes is a widely spread metabolic disease that involves disturbances in the glucose, lipid and mineral levels, as well as in redox reactions. One of the major risk factors in diabetes is the cardiovascular disease and its complications. Several biochemical parameters such as hypercholesterolemia, hyperhomocysteinemia and the reactive species
are considered aggravating factors for the diabetes. The first therapeutic option in diabetes is to lower glucose levels and most often to decrease these major risk factors. The study investigated the influence of a new rutin derivative (coded L3) on the previously mentioned risk factors in experimentally-induced diabetes in rats.

Top