SYNTHESIS OF SOME 1,4-DISUBSTITUTED
THIOSEMICARBAZIDES AS INTERMEDIATES
FOR THE SYNTHESIS OF 1,3,4-THIADIAZOLE
DERIVATIVES
TUNDE HORVATH1*, GEORGETA ŞERBAN1, STELA CUC2
1University of Oradea, Faculty of Medicine and Pharmacy,
Pharmaceutical Chemistry Department, 29 Nicolae Jiga, 410028
Oradea, Romania
2University of Waterloo, Department of Earth Sciences, Environmental
Isotope Laboratory, Waterloo, Ontario, Canada
*corresponding author: tundeh75@gmail.com
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Abstract:

The 4-phenyl-1-[α-acylamino-β-(p-X-phenyl)]acriloyl thiosemicarbazides 3a-h were synthesized using 2-R-4-(p-X-benzylidene)-oxazol-5-ones 1a-h as starting materials.
The reaction of compounds 1a-h with hydrazine hydrate led to the formation of acid hydrazides 2a-h. The thiosemicarbazide derivatives 3a-h were obtained by nucleophilic addition of corresponding acid hydrazides 2a-h to phenylisothiocyanate. The newly synthesized compounds structures were elucidated by spectral data and elemental analysis.






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