PERFORMANCE OF POLOXAMER 407 AS
HYDROPHILIC CARRIER ON THE BINARY
MIXTURES WITH NIMESULIDE
MAHMOUD EI-BADRY1,2*, MAHA A. HASSAN1,2, MOHAMED A.
IBRAHIM1,3, HANAA ELSAGHIR1
1Department of Pharmaceutics, College of Pharmacy, King Saud
University, PO Box 2457, Riyadh 11451, Saudi Arabia.
2Department of Pharmaceutics, Faculty of Pharmacy, Assiut University
71526, Assiut, Egypt.
3Department of Pharmaceutics and Industrial Pharmacy, Faculty of
Pharmacy, Al-Azhar University, Assiut, Egypt.
*corresponding authors: melbadry14@yahoo.com
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Abstract:

A solid dispersion (SD) approach has been performed to enhance the dissolution rate of insoluble drugs by improving their aqueous solubility. An insoluble drug, nimesulide (Nims), was chosen as a model for non-steroidal anti-inflammatory drugs. It was dispersed in a water-soluble carrier poloxamer 407. Different methods were employed to prepare such dispersion, namely: Solvent method (SM), Melting method (MM) and
Kneading method (KM) in different drug: carrier ratios. Nims solid dispersions were characterized for their physicochemical properties using scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and the powder X-ray diffractometry (XRD).

Erratum
The article “Performance of poloxamer 407 as hydrophilic carrier on the binary mixtures with nimesulide”, by Mahmoud Ei-Badry et al. published in Farmacia, volume 61(6) 2013, contains an error in the Acknowledgements section:
The  research group project No. RGP-VPP-093
should be replaced with RGP-VPP-299.

 

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