SYNTHESIS OF NEW THIOUREAS DERIVED FROM 2-
(3,4-DIMETHYL-PHENOXYMETHYL)- AND 2-(2,3-
DIMETHYL-PHENOXYMETHYL)-BENZOIC ACID WITH
POTENTIAL ANTIMICROBIAL ACTIVITY
DRAGOŞ-FLORIAN CIOLAN ¹ ̽ , DUMITRU LUPULEASA²
University of Medicine and Pharmacy „Carol Davila” Bucharest,
Faculty of Pharmacy, 6 Traian Vuia street, 020956, Bucharest, Romania
¹Department of Pharmaceutical Chemistry
²Department of Pharmaceutical Technology and Biopharmaceutics
̽ corresponding author : dragos.ciolan@yahoo.com
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Abstract:

This paper presents the continuation of previous research regarding the synthesis of new thioureas derived from 2-(3,4-dimethyl-phenoxymethyl)-benzoic acid and also the new synthesis of thioureas derived from 2-(2,3-dimethyl-phenoxymethyl)-benzoic acid prepared by adding various primary aromatic amines to 2-(3,4-dimethyl-phenoxymethyl)- benzoyl-isothiocyanate respectively to the 2-(2,3-dimethyl-phenoxymethyl)-benzoylisothiocyanate.
We confirmed the chemical structure and the purity of the original compounds by ¹H-NMR, ¹³C- NMR spectral data, IR spectra and using elemental analysis.

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