SYNTHESIS, CHARACTERIZATION AND
ANTIMICROBIAL ACTIVITY EVALUATION OF
NEW AGENTS FROM BENZAMIDES CLASS
DIANA CAMELIA NUŢĂ1*, MARIANA CARMEN CHIFIRIUC2,
CONSTANTIN DRĂGHICI3, CARMEN LIMBAN1, ALEXANDRU
VASILE MISSIR1, LAURENŢIU MORUŞCIAG1
1University of Medicine and Pharmacy „Carol Davila” Bucharest,
Faculty of Pharmacy, Department of Pharmaceutical Chemistry,
Bucharest, Romania, 6 Traian Vuia St., Bucharest, 020956, Romania
2University of Bucharest, Faculty of Biology, Microbiology-Immunology
Department, 1-4 Ale. Portocalelor, Bucharest 60101, Romania
3The Organic Chemistry Center of Romanian Academy “C. D.
Neniţescu”, Splaiul Independenţei 202B, Bucharest, Romania
*corresponding author: diananuta@yahoo.com
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Abstract:

The use of most antimicrobial agents is limited, not only by the rapid
developement of drug resistance, but also by the unsatisfactory status of present treatment of bacterial infections and drug side effects. This paper is a continuation of our research performed in order to develop new fluoro-trifluoromethyl-substituted benzamides with an improved antimicrobial profile, which targets the ideal antiseptic characteristics. These new
fluoro-trifluoromethyl-substituted N- (2 - diethylaminoethyl) - N - (2,6 - dimethylphenyl) - benzamides (hydrochlorides) were characterized in terms of spectral and antimicrobia action, presenting a broad spectrum of action that was correlated with molecular substitution.

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