SYNTHESIS OF SOME NOVEL THIAZOLES,
BISTHIAZOLES, THIAZOLIN-4 ONES AND 1,3,4
THIADIAZOLINE COMPOUNDS STARTING
FROM 5-ACETYL-2-PHENYL-4-METHYLTHIAZOLYL-
THIOSEMICARBAZONE
SMARANDA ONIGA1, BRÎNDUŞA TIPERCIUC1, MARIANA
PALAGE1*, ADRIAN PÎRNĂU2, PHILIPPE VERITE3, OVIDIU
CRIŞAN1, OVIDIU ONIGA1
1Faculty of Pharmacy, „Iuliu Haţieganu”, University of Medecine and
Pharmacy, 12 Ion Creangă Street, 400023, Cluj-Napoca, Romania
2National Institute for Research and Development of Isotopic and
Molecular Technologies, RO-400293 Cluj Napoca, Romania
3University of Medicine and Pharmacy Rouen, Faculty of Pharmacy, 22
Boulevard Gambetta, F-76183 Rouen Cedex, France
*corresponding author: mpalage@umfcluj.ro
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Abstract:

A new series of 5-thiazolyl-ethylidene-hydrazinyl-thiazoles 3a-g, 5-thiazolilethylidene- hydrazinyl-thiazolin-4-ones 5 and 6a-i was synthesized starting from 5-acetyl-2- phenyl-4-methyl-thiazolyl-thiosemicarbazone 2 by the reaction with various α- halocarbonyle compounds or ethyl-α-chloroacetate. The 5-thiazolyl-1,3,4-thiadiazoline 4 was synthesized by ciclysation of the same thiosemicarbazone 2 with acetic anhydride in
the presence of pyridine. The newly synthesized compounds were characterized by 1HNMR and mass spectral studies.






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