THE CORRELATIONS BETWEEN PLASMA
LEPTIN AND THE CONCENTRATIONS OF
PROINFLAMMATORY CYTOKINES IN
PATIENTS WITH TYPE II DIABETES
MELLITUS IN MAINTENANCE
HEMODIALYSIS
ANGELA ANTONESCU1, OTILIA MICLE1*, SIMONA IOANA
VICAŞ2, GABRIEL BAKO3, CAMELIA MRAZ1, LAURA VICAŞ4,
MARIANA MUREŞAN1
1University of Oradea, Medicine and Pharmacy Faculty, Department of
Preclinical Disciplines, Oradea, Romania
2University of Oradea, Faculty of Environmental Protection, Oradea,
Romania
3University of Oradea, Medicine and Pharmacy Faculty, Department of
Internal Medicine, Oradea, Romania
4University of Oradea, Medicine and Pharmacy Faculty, Department of
Pharmacy, Oradea, Romania
*Corresponding author: micleotilia@yahoo.com
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Abstract:

The goal of the study was to asses the serum level of leptin and to establish if there is a relationship between leptin and proinflammatory cytokines in diabetic and nondiabetic patients submitted to chronic hemodialysis.
The study included 20 type II diabetic patients and 15 non-diabetic patients in maintenance hemodialysis. A group of 30 healthy age-matched subjects were used as control. The serum levels of leptin and inflammatory cytokines were determined: IL-6 (Interleukin 6), IL-8 (Interleukin 8), TNF-α (Tumor necrosis factor) before and after hemodialysis.
The diabetic female patients on dialysis have leptin, TNF-α, IL-8 levels
significantly higher than in control group (p<0.0001). Leptin did not show critical differences in the three male groups (p>0.05). A negative correlation was detected only in diabetic female patients between serum ferritin and serum leptin (Pearson index -0.6062) and a positive correlation with BMI (Body mass index), (Pearson index 0.6657).
Serum leptin levels in hemodialysed patients with type II diabetes mellitus do not differ significantly from those of hemodialysed non-diabetic patients.

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