EXPERIMENTAL PHARMACOLOGICAL
RESEARCHES REGARDING THE INFLUENCE OF
SODIUM FLUORIDE IN ALLOPATHIC AND
HOMEOPATHIC DOSES ON CENTRAL NERVOUS
SYSTEM’S PERFORMANCES. A CORRELATION
BETWEEN BEHAVIORAL RESPONSE IN CLASSIC
MAZE TEST AND MORPHOLOGICAL ASPECTS OF
CEREBRAL CORTEX
VIOLETTA BĂRAN-POESINA1, SIMONA NEGREŞ2*, DUMITRU
DOBRESCU2, NICOLETA DIMCEVICI-POESINA2, ANDREEA
DIMCEVICI-POESINA3, ADRIAN FEGHIU4, THEODOR SOARE4,
MANUELLA MILITARU4
1Dental - Sinus VPB, Bucharest, Romania
2University of Medicine and Pharmacy “Carol Davila”, Faculty of
Pharmacy, Str. Traian Vuia 6, Bucharest, Romania
3Farmacia Catena, Bucharest, Romania
4Faculty of Veterinary Medicine, Bucharest, Romania
*corresponding author: simona_negres@yahoo.com
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Abstract:

The influence of fluorine administration on central nervous system’s (CNS)
performances in female mice treated during gestation with two distinct doses of sodium fluoride (NaF): 0.25 mg and 0.50 mg. The research extended also to offspring (generation 1 – F1), treated with NaF in allopathic (0.25 and 0.50 mg), homeopathic (7CH) or with the
association between the two types (allopathic and homeopathic) of doses. CNS performance modification was also assessed in the second generation offspring (F2), in which fluorine was exclusively taken from ascendant generations. Evaluation of CNS activity was performed by determining clearing time in classic maze (CM) at several time intervals (roughly 21 days between determinations). Experimental results showed that, in
young offspring (1 – F1) from ascendants treated with the same substance, CNS performances in investigative capacity are influenced depending on dose, gender and age.
Similar effect was recorded for homeopathic remedy 7CH for which the influence on CNS performance is strongly correlated to the stage of physical development of offspring and to doses of NaF administered to ascendants. The results of pharmacological tests correlate strongly to modifications noted during anatomical pathology examination of cerebral cortex.

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