EFFECTS OF BOTULINUM TOXIN-TYPE A IN
THE TREATMENT OF CEREBRAL PALSY IN
CHILDREN
IULIANA ŞTEFANIA DINU1, HOUSSEIN TOUFIC SEBLANY1*,
MONICA SAFER2, DOINA ANCA PLEŞCA2
1University of Medicine and Pharmacy „Carol Davila”, Dionisie Lupu
37 street, 2nd district, Bucharest
2Department of Pediatrics and Pediatric Neurology, „Victor Gomoiu”
Children Clinical Hospital, University of Medicine and Pharmacy „Carol
Davila”, Dionisie Lupu 37 street, 2nd district, Bucharest
*corresponding author: housseinovici@yahoo.com
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Abstract:

Cerebral palsy (CP) is a chronic disorder of movement and/or posture that
presents early (before the age of 2) and continues throughout life. CP is caused by static injury (non-progressive damage to the brain before, during or after birth) to the developing brain. CP is a permanent disease which cannot be cured, but the consequences can be minimized. Spasticity represents a major neuromuscular problem in CP and the children
can be hemiplegic, diplegic or quadriplegic. Botulinum toxin (BTX) is one of the most useful antispastic agents used as treatment for spastic CP in children.
The aim was to study the effects of BTX on motor function in children with
different forms of spastic CP. Spasticity was clinically assessed using Modified Ashworth Scale (MAS). The results showed the efficacy of BTX in diplegia, hemiplegia, quadriplegia.

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