SYNTHESIS AND CHARACTERIZATION OF A
CARBOXYLIC ACID DERIVATIVE FOR
LIPOSOMAL PREPARATIONS
CĂTĂLINA IONESCU1, SIMONA CRISTINA RIZEA1, VÉRONIQUE
BARRAGAN-MONTERO2, JOHNY NEAMȚU1*
1Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova,
Str. Petru Rareş nr. 2-4 Craiova 200349, Dolj, România
2Equipe SyGReM, Institut des Biomolécules Max Mousseron, Université
Montpellier 2, UMR 5247, CNRS-UM1-UM2, ENSCM, 8, rue de l’Ecole
Normale, 34296 Montpellier cedex 05, France
*corresponding author: j.neamtu@yahoo.com
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Abstract:

A new compound with cholesteryl-derived structure containing a carboxylic acid functional group has been prepared in four steps starting from cholesterol. The product has been characterized by 1H, 13C NMR and mass spectrometry analysis. It will be used for liposomal preparations, in order to evaluate the interaction of liposomes functionalized with
carboxylic acid functional groups and hydroxyapatite.

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