SYNTHESIS OF NEW UNSYMMETRICAL 1,4-
DIHYDROPYRIDINE DERIVATIVES AS
POTENTIAL ANTICANCER AGENTS
LAURENŢIU MORUŞCIAG1, CONSTANTIN DRĂGHICI2, GEORGE
MIHAI NIŢULESCU1*
1University of Medicine and Pharmacy „Carol Davila”, Faculty of
Pharmacy, 6 Traian Vuia, 020956, Bucharest, Romania
2The Organic Chemistry Center of Romanian Academy “C.D.
Neniţescu”, Splaiul Independenţei 202B, Bucharest, Romania
*corresponding author: nitulescu_mihai@yahoo.com
DownloadDownload Full Article

Abstract:

The 1,4-dihydropyridine structure is a very versatile and drug feasible template allowing multiple structural modulations and the resulted molecules can exert potent and selective actions on a large spectrum of biological targets. As a continuation of our previous
research focused on the 1,4-dihydropyridine scaffold we designed and synthesized some new methyl 5-alkyl/aryl-carbamoyl-2,6-dimethyl-4-(substituted-phenyl)-1,4-dihydro pyridine-3-carboxylate derivatives. The obtained compounds were characterized by elemental, IR and NMR analyses and are proposed for antitumor evaluation.






Top