SOLID-STATE CHARACTERIZATION OF
BIFONAZOLE - RANDOM METHYL-BETACYCLODEXTRIN
BINARY SYSTEMS
CRISTINA TRANDAFIRESCU1*, ÁRPÁD GYÉRESI2, ZOLTÁN
SZABADAI3, CRISTINA PĂTRUŢESCU 1, MIHÁLY KATA4,
ZOLTÁN AIGNER4
1Victor Babeş University of Medicine and Pharmacy, Faculty of
Pharmacy, Department of Pharmaceutical Chemistry, 1st Eftimie Murgu
Str., Timişoara, România
2 University of Medicine and Pharmacy, Faculty of Pharmacy,
Department of Pharmaceutical Chemistry, 38th Gheorghe Marinescu Str.,
Târgu-Mureş, România
3 Victor Babeş University of Medicine and Pharmacy, Faculty of
Pharmacy, Department of Drug Analysis, 1st Eftimie Murgu Str.,
Timişoara, România
4University of Szeged, Faculty of Pharmacy, Department of
Pharmaceutical Technology, 6th Eötvös Str., Szeged, Hungary
*corresponding author: cristinatrandafirescu@gmail.com
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Abstract:

The aim of this paper was to investigate the interaction in solid state between the antimycotic agent bifonazole with random methyl-β-cyclodextrin. The binary systems between bifonazole and random methyl-β cyclodextrin were prepared in four molar ratios, by two methods. The interaction between the components was characterized by thermal and
spectral methods.






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