THE IMPACT OF DISSOLUTION MEDIA ON THE
SIMILARITY OF RELEASE PROFILES OF
TRIMETAZIDINE DIHYDROCHLORIDE FROM
IMMEDIATE RELEASE TABLETS
MOURAD ALI1, MIRON DALIA SIMONA2*, LUPULEASA
DUMITRU1, KARAMPELAS OANA1, RĂDULESCU FLAVIAN
ȘTEFAN3, DRAGANESCU DOINA4, ROȘCA ADRIAN COSMIN5
University of Medicine and Pharmacy „Carol Davila” Bucharest,
Faculty of Pharmacy, 6 Traian Vuia street, 020956, Bucharest, Romania
1Department of Pharmaceutical Technology and Biopharmaceutics,
2Department of Pharmaceutical Physics and Informatics,
3Department of Drug Industry and Pharmaceutical Biotechnologies.
4Department of Pharmaceutical Physics and Informatics
5Department of Drug Analysis, Faculty of Pharmacy, "Ovidius"
University of Constantza, Romania
*corresponding author: dalia_simona_m@yahoo.com
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Abstract:

The paper presents the impact of the composition of the dissolution media
(water, hydrochloric acid pH=1.2 and phosphate buffer pH=6.8) on the in vitro release profiles of four immediate release formulations containing 20 mg trimetazidine dihydrochloride. The results suggest that, for quality control purposes, the most discriminatory test conditions are provided by the acidic media.






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