EVALUATION OF ANTIMICROBIAL ACTIVITY
OF SOME TYPES OF INCLUSION COMPLEXES
OF ERYTHROMYCIN WITH β-CYCLODEXTRIN
ON STAPHYLOCOCCUS AUREUS
ELEONORA MARIAN1*, MARIANA MURESAN2, TUNDE JURCA1,
LAURA VICAS1
1University of Oradea, Medicine and Pharmacy Faculty, Department of
Pharmacy, 29 Nicolae Jiga Str., 410028, Oradea, Romania
2University of Oradea, Medicine and Pharmacy Faculty, Department of
Preclinical Disciplines, 10 1 December Str., Oradea, Romania
*corresponding author: emarian@uoradea.ro
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Abstract:

Erythromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration. The purpose of this study was to evaluate the antimicrobial activity of the inclusion complexes of erytromycin with β-cyclodextrin synthesized by three methods: kneading, co-precipitation and freeze-drying.
The inclusion compounds were synthesized using a molar ratio of erythromycin: β-cyclodextrin of 1:1.
To determine the antimicrobial activity of erythromycin and its inclusion
complexes, we used the disk diffusion method on Muller-Hinton medium and
Staphylococcus aureus ATCC 25923 was used as quality control organisms.
Our determinations showed that the tested complexes erythromycin- β –
cyclodextrin had a strong antimicrobial activity.

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