EFFICACY AND TOLERABILITY OF
TIANEPTINE IN DEPRESSED PATIENTS WITH
CARDIO-VASCULAR DISEASES
MARIA LADEA*, MIHAELA CRISTINA SINCA, DAN
PRELIPCEANU
Clinical Hospital of Psychiatry “Prof.Dr.Alexandru Obregia”,
Bucharest, Romania
*corresponding author: marialadea@gmail.com
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Abstract:

The symptoms of depression and those of cardiovascular disease (CVD) overlap substantially. Differentiating between dimensions of depressive symptoms may improve our understanding of the relationship between depression and physical health, in order to find a more adequate antidepressant treatment for patients having both depression and
cardiovascular disease. Our aim was to assess the efficacy, tolerability and safety of tianeptine in depressed patients with moderate and severe cardio-vascular disorders. The present survey is an observational naturalistic study conducted in patients with important cardio-vascular disorders who underwent evaluation for depressive symptoms, using the Montgomery Asberg Depression Rating Scale (MADRS) and the selfevaluation
Hospital Anxiety and Depression Scale (HADS). The MADRS and HADS were used to examine the efficacy of tianeptine after 28 days of antidepressant therapy. Tolerability of tianeptine and its effects on cardiovascular system was assesed. Fifty eight hospitalized patients meeting DSM-IV TR (Diagnostic and Statistical Manual of Mental Disorders, forth edition, text revision) criteria for major depressive disorder, severe or moderate episode, who also had important cardio-vascular disorders:
arterial hypertension, cardiac failure and ischemic heart disease were included in the study The cardio-vascular disorders were clinically stable under specific treatment. Two ECG were performed: one at baseline and one after two weeks of treatment. The patients received 3 tablets of tianeptine 12.5 mg per day, and were monitored for 28 days regarding
both efficacy and tolerability of the treatment.[...]

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