PHYSICOCHEMICAL INTERACTION OF
NAPROXEN WITH ALUMINIUM HYDROXIDE
AND ITS EFFECT ON DISSOLUTION
SHWETA PAROHA1, RAVINDRA DHAR DUBEY2, SUBRATA
MALLICK1*
1School of Pharmaceutical Sciences, Siksha O Anushandhan University,
Bhubneswar-751003, Orissa, India.
2Indian Institute of Integrative Medicine (CSIR), Jammu, Jammu &
Kashmir -180001, India.
*corresponding author: s_mallickin@yahoo.com
Download Full Article

Abstract:

The interaction study of naproxen with aluminium hydroxide has been carried out in both solid state and wet state. Naproxen was co-milled in the solid state and colyophilized after overnight wet equilibration in different weight ratios. Physicochemical characterization of the interaction was carried out using analytical techniques such as Fourier transform infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC)
and Scanning electron microscopy (SEM) studies. In vitro dissolution studies were also performed to examine the effect of interaction on dissolution. FTIR spectra suggested an acid–base interaction between the carboxylic acid containing naproxen and aluminium hydroxide. DSC thermogram confirmed the absence of complexation between naproxenaluminium hydroxide and SEM study indicated the presence of stabilized microparticles containing cluster of nano- and submicron drug crystals associated with aluminium hydroxide. In vitro dissolution studies revealed the improved release of naproxen from formulated powder samples

Top