MODELLING OF TRANSFER KINETICS OF
TRICHLORPHON PESTICIDE ACROSS
CUPROPHANE DIALYSIS MEMBRANE IN
PRESENCE AND ABSENCE OF ANTIDOTE
POWDERS
GHEORGHE CORLAN, GABRIELA PAHOMI, ROXANA
SANDULOVICI, IRINA PRASACU, MIHAELA IONESCU,
VALENTINA ANUTA*
1”Carol Davila” University of Medicine and Pharmacy, 37 Dionisie
Lupu St., Bucharest, Romania
*corresponding author: vali_anuta@yahoo.com
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Abstract:

The objectives of the paper were to analyse and to model the data concerning diffusion through a membrane with or without adsorptive powders of a hydrophilic organophosphorous pesticide, Trichlorphon (TCP), using in vitro experimental models and to estimate the antidote efficacy of an adsorptive powder. Data concerned the in vitro transfer across a dialysis membrane using a static Franz diffusion cell battery and a flow through cell system. A mixture of cellulose acetate powder and bentonite powder was applied on the membrane in order to reduce the transfer of toxics across membrane.
As mathematical models, linear biphasic regression was tested, first order
kinetics and a square root law derived from diffusion equation. Fitting of experimental data with theoretical models was performed using least square methods. For selecting one or two phase linear regression models it was used the F-test. The release kinetics was biphasic: a first model for 50 – 60 % of the transfer of available fraction of toxic, followed by a more or less saturation phase. Adsorptive powder applied as antidote candidate significantly reduced the amount of transferred Triclorfon across membrane – at least for some hours, suggesting a possible similar effect at the level
of intact skin. Presence of powders changed the mathematical transfer model from a model dominated by a first order kinetic to a square root model

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