IN VITRO EVALUATION OF DIFFUSION AND
RHEOLOGICAL PROFILES FOR
DEXAMETHASONE INCLUSION COMPLEXES
WITH β-CYCLODEXTRIN OR
HYDROXYPROPYL β-CYCLODEXTRIN
MARIUCA-ROXANA GAVRILOAIA1*, EMMA-ADRIANA BUDURA1,
CLAUDIA CRINA TOMA2, MIRELA ADRIANA MITU1, OANA
KARAMPELAS1, CORINA ARAMA3, DUMITRU LUPULEASA1
1Pharmaceutical Technology Department, Faculty of Pharmacy, University
of Medicine and Pharmacy „Carol Davila” Bucharest, 6 Traian Vuia St.,
020956, Bucharest, Romania
2Department of Pharmacognosy. Phytochemistry. Phytotherapy, Faculty of
Pharmacy, "Vasile Goldis" Western University of Arad, 1 Feleacului
Street, 300041, Romania
3Analitical Chemistry Department, Faculty of Pharmacy, University of
Medicine and Pharmacy „Carol Davila” Bucharest, 6 Traian Vuia St.,
020956, Bucharest, Romania
*corresponding author: roxana21g@yahoo.com
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Abstract:

Dexamethasone (Dmt), is very potent glucocorticoid, and inclusion complexes formed with cyclodextrins (Cd), enhance skin penetration. Five gels were prepared representing combinations of the drug with lyophilized or simple physical mixtures of β- cyclodextrin (Bcd), or hydroxypropyl β- cyclodextrin (HBcd), in the 1:1 molar ratio. The paper presents in vitro measured values of these forms by using a vertical diffusion cells
system and a rotational rheometer. The experimental conditions represented an adaption of the USP Topical/Transdermal Ad Hoc Advisory Panel stimuli for revision process. The aim of this study was to evaluate the improving of skin penetration by Dmt in different mixtures with two Cd, by using the drug release and rheological profiles. Diffusion coefficients of Dmt inclusion complexes with Cd significantly increased compared with the single use of Dmt. The best released rate of Dmt was obtained
for the lyophilized inclusion complex with Bcd. A significant diffusivity increase was noticed for the physical mixtures. Data fitted five kinetic models approximating the diffusion profiles. The Korsmeyer–Peppas model gave the best correlation between measured and interpolated data.
All the rheological investigated gels presented shear-thinning and thixotropic behavior. A nonlinear model fitted the rheological data. The obtained profiles suggest better performances of Dmt inclusion complexes for topical applications.




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