ACITRETIN TREATMENT IN PSORIAZIS MAY
INFLUENCE THE CELL MEMBRANE FLUIDITY
CAROLINA NEGREI1, ANDREEA LETIŢIA ARSENE2, CORINA
DALIA TODERESCU3, DANIEL BODA4*, MIHAELA ILIE1
1Department of Toxicology, “Carol Davila” University of Medicine and
Pharmacy, 6, Traian Vuia street, Bucharest, Romania
2Department of Biochemistry, Faculty of Pharmacy, “Carol Davila”
University of Medicine and Pharmacy, Traian Vuia 6, Bucharest,
Romania
3”Vasile Goldis” Western University of Arad, 91-93, L. Rebreanu Str.,
Arad, Romania
4Center of Excellence in Dermato-oncology, “Carol Davila” University
of Medicine and Pharmacy, 22-24 Gr. Manolescu street, Bucharest,
Romania
*corresponding author: daniel.boda@yahoo.com
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Abstract:

Psoriasis is a chronic recurring condition that varies in severity from minor
localized patches to complete body coverage. In this disease the normal cycle of replacing old skin cells with new one becomes unbalanced. The most popular parameter to characterise plasma membrane is fluidity. The membrane fluidity in psoriatic patients decreases. The present paper is intended to review the literature data on the possible involvement of membrane fluidity in psoriatic patients; a special focus is given to patients treated with acitretin.

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