ASSESSING DEPRESSIVE EFFECT OF
KETOPROFEN AND ITS MECHANISM OF
ACTION USING THE FORCED SWIMMING TEST
IN MICE
ILEANA RĂDUCANU1*, ANA SEGÂRCEANU2, GABRIEL PRADA1,2,
CRISTINA IONESCU1, ANDREEA ARSENE2, ION FULGA2
1 “Ana Aslan” National Institute of Gerontology and Geriatrics, Bucharest
2 “Carol Davila” University of Medicine and Pharmacy, Bucharest
*corresponding author: ileanaghraducanu@yahoo.com
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Abstract:

The mood effect of non-steroidal anti-inflammatory drugs (NSAIDs) is a matter of debate concerning clinical and experimental data as well. This paper presents the mood effect of ketoprofen in mice during the forced swimming test. In three series of laboratory animal groups, the mobility time was significantly shorter than that in controls supporting a ketoprofen depressant effect. Administering amitriptyline and fluoxetine, but not mianserin, antagonized the depressant effect of ketoprofen. These data point out that ketoprofen when administered on longer term has an effect on mood acting only at the serotonin level (receptors or metabolism).

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