ANTIBIOTIC POTENTIATOR EFFECT OF THE
NATURAL AND SYNTHETIC ZEOLITES WITH
WELL DEFINED NANOPORES WITH POSSIBLE
ENT CLINICAL APPLICATIONS
ION ANGHEL1*, ALEXANDRU MIHAI GRUMEZESCU2, ALINA
GEORGIANA ANGHEL3, IULIAN CHIREAC4, LUMINITA
MARUTESCU4, DAN EDUARD MIHAIESCU2, MARIANA CARMEN
CHIFIRIUC4
1University of Medicine Carol Davila Bucharest, Romania
2 Politehnica University of Bucharest, Faculty of Applied Chemistry and
Materials Science, Bucharest, Romania
3ENT (Otorhinolaryngology) Clinic, Coltea Hospital, Bucharest,
Romania
4University of Bucharest, Faculty of Biology, Microbiology Immunology
Department, Bucharest, Romania
*corresponding author: ionangheldoc@yahoo.com
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Abstract:

An adapted difussimetric method was used in order to assess the potentiator effect of some natural (NZ) and synthetic zeolites (SZ)with well defined nanopores on the antibiotic (ATB) susceptibility of Enterococcus fecalis, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis and Escherichia coli strains to some of the currently used antibiotics, i.e. neomycin, polymixin, norfloxacin and cefotaxime. Our results show that the natural and synthetic zeolites with well defined nanopores release antibiotics with different chemical structures in an active form and improve their antimicrobial effect against Gram-positive and Gram-negative bacterial strains, constituting promissing delivery systems for various classes of commonly used antibiotics.

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