SPECTROPHOTOMETRIC DETERMINATION OF
BISOPROLOL USING METHYL ORANGE AS
REAGENT
ALINA DIANA GUDRUMAN*, ANDREEA MURĂRAŞU, VASILE
DORNEANU
University of Medicine and Pharmacy ″Gr.T.Popa″ of Iasi, Faculty of
Pharmacy, Analytical Chemistry Department, 16 University Street, Iasi,
700115, Romania
*corresponding author: alinadiana74bis@yahoo.com
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Abstract:

A spectrophotometric method for the quantitative determination of bisoprolol was established based on the formation of an ion pair complex between bisoprolol and methyl orange, in acid medium, extractable in dichloroethane, with a maximum absorbance at 427 nm. The limit of detection (LoD) was 0.20 μg/mL and the limit of quantification (LoQ) was 0.66 μg/mL. The elaborated method was validated.




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