EFFECTS OF THE PELOID CREAM FROM THE
MONTENEGRIN ADRIATIC COAST ON SKIN
HUMIDITY, TRANSEPIDERMAL WATER LOSS
AND ERYTHEMA INDEX, EXAMINED WITH SKIN
BIOENGENEERING IN VIVO METHODS
ZORICA POTPARA1*, NATAŠA DUBORIJA-KOVAČEVIĆ2,3
1 Faculty of Pharmacy, University of Montenegro, Department of
Pharmaceutical Technology, Podgorica, Montenegro
2 Faculty of Medicine, University of Montenegro, Department of
Pharmacology and Clinical Pharmacology, Podgorica, Montenegro
3 Faculty of Pharmacy, University of Montenegro, Department of
Pharmacology, Podgorica, Montenegro
*corresponding author: fontis@t-com.me
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Abstract:

The healing properties of mineral mud (peloid) have been used for centuries for medicinal and cosmetic purposes. In this study there were studied in vivo effects of locally applied peloid from the Montenegrin Adriatic coast on the skin humidity-hydration level of the stratum corneum (SCH), transepidermal water loss (TEWL) and erythema index (EI).
Examination of the effects of peloid in the form of 1% of cream (P cream) on SCH, TEWL and EI was carried out at the Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy in Belgrade, using modern skin bioengineering in vivo methods. Short-term (one hour) and long-term (one month) in vivo studies on 20 healthy volunteers aged 24 ± 1.2 years on the volar part of the forearm were conducted. One-way
ANOVA and post-hoc Tukey test were used for statistical analysis of data.
There was noticed a is statistically significant difference (p<0.05) in stratum corneum humidity, expressed as arbitrary units in the group treated with P cream for each observation period, in comparison to the baseline values, as well as with the control group. Percentage of the change in TEWL value after a month of using P cream was not statistically significant (p>0.05).
Statistically, EI values were not significantly increased (p>0.05) in any time point for the tested P cream, while there was an increase of this parameter in the case of untreated control.
In conclusion, P cream has a beneficial hydrating effect, it doesn't lead to the breaking of the skin barrier, and irritation potential during single use, as well as continuous usage for skin care was not manifested.




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