DETERMINATION OF THE ENANTIOMERIC
RATIO OF WARFARIN IN TABLETS BY
MULTIVARIATE CALIBRATION AND
MODELING OF SPECTROSCOPIC DATA
EDE BODOKI*, IOANA TIUCA, BOGDAN-CEZAR IACOB, OANA
HOSU, RADU OPREAN
Iuliu Hatieganu University of Medicine and Pharmacy, Dept. of
Analytical Chemistry, 13, Emil Isac St., 400023 Cluj-Napoca, Romania
*corresponding author: bodokie@umfcluj.ro
Download Full Article

Abstract:

Considering the constant need to develop high performance, selective and robust analytical chiral methods, the aim of the present work was the determination of enantiomeric excess of warfarin by multivariate calibration and modeling of spectral data.
Chromatographic and electrophoretic chiral separations have proven their value, offering good selectivity and low limits of quantification; however they may also require lengthy and expensive method development and prolonged analysis times.
In this paper we have developed a simple method for the determination of the chiral purity of warfarin from tablets by chemometric spectroscopic calibration, using tbutyl- calix[6]arene as chiral selector. The obtained results were confirmed also by chiral high-performance liquid chromatography

Top