EXPERIMENTAL PHARMACOLOGICAL
RESEARCH REGARDING THE ANTI-OBESITY
EFFECT AND THE MOTOR BEHAVIOR
INDUCED BY SOME NEWLY SYNTHETIZED β3
ADRENERGIC RECEPTORS AGONISTS IN
NORMAL MICE
EMIL ŞTEFĂNESCU1, AURELIA NICOLETA CRISTEA1, CORNEL
CHIRIŢĂ1*, GABRIELA PUTINA2
1Faculty of Pharmacy, University of Medicine and Pharmacy Carol
Davila – Traian Vuia str. no. 6 – Bucharest
2Romanian National Institute of Chemical-Pharmaceutical Research and
Development – Bucharest
* corresponding author: chirita.cornel@gmail.com
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Abstract:

A series of newly synthesized compounds by the Romanian National Institute of Chemical-Pharmaceutical Research and Development Bucharest were studied. These compounds are structurally similar to a series of β3 adrenergic receptors agonists, some of which being under clinical trials. The research was directed towards investigating the effect
of these compounds on the eating behavior of mice and their body mass evolution, taking into account the fact that the scientific literature already mentions some anti-obesity effects of the β3 agonists. Experimental trials were also performed in order to observe if the new compounds influence the activity of the central nervous system. Thus was determined the
motor activity. The new substances were conventionally named C1, C2, C3, C6. From all studied compounds, C3 showed one of the highest prevention of the weight gain in mice, without influencing the motor activity

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