COMPARATIVE IN-VITRO STUDY OF
IMMEDIATE AND MODIFIED RELEASED ORAL
DOSAGE FORMS OF CEFACLOR
BURCEA DRAGOMIROIU GEORGE TRAIAN ALEXANDRU1,
MIRON DALIA SIMONA2*, BALOESCU CORNELIU1, BÂRCĂ
MARIA1, MITU MIRELA ADRIANA3, POPA DANIELA ELENA1,
RĂDULESCU FLAVIAN ȘTEFAN4
University of Medicine and Pharmacy „Carol Davila” Bucharest,
Faculty of Pharmacy, 6th Traian Vuia street, 020956, Bucharest,
Romania.
1Department of Drug Control,
2Department of Pharmaceutical Physics and Informatics,
3Department of Pharmaceutical Technology and Biopharmaceutics,
4Department of Drug Industry and Pharmaceutical Biotechnologies.
*corresponding author: dalia_simona_m@yahoo.com.
Download Full Article

Abstract:

The paper presents the results of in vitro dissolution testing for various
immediate and controlled release formulations of cefaclor, based on compendial recommendations and specific methodological adaption. The data suggest a rapid and complete release for capsules and suspensions dosage forms, the profiles being independent on dose-strength. The sinkers used for preventing the floating phenomenon did not influence significantly the dissolution pattern. For modified release film-coated tablets, the paddle apparatus provided similar results compared to USP30 pharmacopoeial conditions

Top