SIMPLE AND FACILE SPECTROPHOTOMETRIC
METHODS FOR THE DETERMINATION OF
AMISULPRIDE IN PHARMACEUTICAL
FORMULATIONS
K.V.V. SATYANARAYANA, T. RAMESH, P. NAGESWARA RAO*
Department of Chemistry, National Institute of Technology, Warangal -
506004, Andhra Pradesh and India
*corresponding author: pnraonitw07@gmail.com
DownloadDownload Full Article

Abstract:

Three simple, sensitive and novel spectrophotometric methods have been
established for determination of amisulpride (ASP) in pharmaceutical dosage forms. The proposed methods are based on the diazotization of ASP with sodium nitrite and hydrochloric acid, followed by coupling with ethyl acetoacetate, 1-benzoyl acetone and 8-hydroxyquinoline in alkaline medium for methods A, B and C respectively. The formed azo dyes are measured spectro-photometrically at 438, 446 and 545 nm for methods A, B and C respectively. Different variables affecting the reactions were optimized. Beer’s law is obeyed over the concentration ranges of 1.0-24.0, 1.0-24.0 and 1.0-20.0 μg/mL for methods A, B, and C, respectively. The results of the proposed methods are validated statistically.
The proposed methods were applied successfully to the determination of ASP in pharmaceutical dosage forms.




Top