THE OPTIMIZATION OF PROLONGED
RELEASE MULTIPARTICULATE TABLETS
WITH BETAHISTINE DIHYDROCHLORIDE –
Part II
RADU CAZACINCU1, MIRCEA HÎRJĂU2*, DUMITRU LUPULEASA2
1Ovidius University, Faculty of Pharmacy, Aleea Universităţii nr.1,
Campus, Corp B, Constanta
2University of Medicine and Pharmacy “Carol Davila”, Faculty of
Pharmacy, Traian Vuia Str. no. 6, Bucharest
*corresponding author: mircea_hrj@yahoo.com
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Abstract:

The influence of some formulation factors on the release of betahistine
dihydrochloride, an active ingredient freely soluble in water, from multiparticulate tablets with prolonged release was studied.
Prolonged release multiparticulate tablets of betahistine dihydrochloride were prepared by compressing prolonged release granules obtained via fluid bed granulation and coating. They were mixed with the suitable excipients (micro-crystalline cellulose -Vivapur type 102 as filler, talcum as lubricant, colloidal anhydrous silica dioxide – Aerosil as glidant).
The fluid bed coating is currently a widely used technique because it allows,
among other applications, the coating of crystals or granules with a variety of available polymers, providing modified release systems [1].
In order to obtain a prolonged release drug delivery system, Eudragit® RL and Eudragit® RS polymers were used as coating agents. The formulation variables studied were the type of the coating polymers and their quantitative ratio, as well as the coating percentages.
The results show that the percentage of polymer used in the tablet formulation has the most significant influence on the drug release.

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