INVESTIGATIONS ON THE IN VITRO RELEASE
MECHANISM OF PROPICONAZOLE NITRATE
FROM HYDROPHILIC GEL FORMULATIONS
LĂCRĂMIOARA OCHIUZ1*, ANDREEA STĂNESCU2, IULIAN
STOLERIU3, VASILE DORNEANU1, IULIANA POPOVICI1,
DUMITRU LUPULEASA2
1University of Medicine and Pharmacy ”Gr. T. Popa”, Iasi, Faculty of
Pharmacy, 16, University Street, 700115, Iasi, Romania
2University of Medicine and Pharmacy”Carol Davila” Bucharest,
Faculty of Pharmacy, 6, Traian Vuia Street, 020956, Bucharest, Romania
3“Al. I. Cuza” University, Faculty of Mathematics, 11, Carol I
Boulevard, 700506, Iasi, Romania
*corresponding author: ochiuzd@yahoo.com
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Abstract:

The aim of this study was the evaluation of the release kinetic of propiconazole nitrate (PN) from different topic formulations. There were prepared six types of suspension ointments with 1.5% PN, using 10% glycerol as wetting agent and enhancer, for formulas F1, F3, F5 and, respectively, 10 % propylene glycol for formulas F2, F4 and F6. The
ointments’ bases were as follows: two ointments based on 4% hydroxypropyl cellulose H (HPC-H), hydrogels (F1, F2); two ointments with polyethylene glycol modified base (F3, F4); and two ointments based on hydrated cetylic ointment (F5, F6). In vitro release of PN from gels was performed using the Enhancer cell of II dissolution apparatus with a semipermeable membrane (cellophane). Quantitative determination of released PN was achieved by an UV spectrophotometric method at λ = 270 nm. In order to evaluate the kinetics of the in vitro PN release from the studied gels, the data were analyzed by the use of four mechanistic kinetic models, as follows: zero order kinetics, first order, Higuchi model and Peppas model. Data fitting was achieved through linear or non-linear regression with the Matlab 7.1 software. The results showed that F1-F4 formulas having as vehicle HPC-H and PEG 300-4000, are best fitted on the exponential model that defines the first order dissolution. The F5-F6 formulas, based on cetylic alcohol are best fitted on the
Higuchi model. There are no significant differences between formulas containing the same polymer but a different type of wetting agent, leading to the conclusion that the latter does not influence the structural properties of the polymers.




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