COMPARISON BETWEEN COCKROFT-GAULT
AND MDRD FORMULA FOR THE ESTIMATION
OF GLOMERULAR FILTRATION RATE IN
CHRONIC KIDNEY DISEASE PATIENTS
CARMEN CĂLDĂRARU1*, MARIA T DOGARU2, CAMIL E. VARI2,
SILVIA IMRE2, GRIGORE DOGARU1
1Nephrology Department, University of Medicine and Pharmacy,
Gheorghe Marinescu street 38, RO-540139, Târgu-Mures, Romania
2Faculty of Pharmacy, University of Medicine and Pharmacy, Gheorghe
Marinescu street 38, RO-540139, Târgu-Mures, Romania
*corresponding author: caldararuc@yahoo.com
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Abstract:

The purpose of this study was to determine the concordance between two equations used for estimating glomerular filtration rate, in order to verify the possibility to be used interchangeably in the clinical practice. We present a retrospective study performed on a group of 258 patients with chronic kidney disease treated between January 2008 and December 2009
in the Department of Nephrology of The County Hospital Targu Mures, Romania. For every patient, glomerular filtration rate (GFR) was estimated with Cockroft-Gault (aCG) equation adjusted for body surface (aCG) and abbreviated Modification of Diet in Renal Disease (MDRD) formula (aMDRD). The paired t-test showed that the estimated GFR through the
abbreviated MDRD and the corrected CG equations were significantly different from each other (p < 0.0001). There were significant differences between glomerular filtration rate estimated with aCG and aMDRD equations (p<0.0001) between groups of patients of different ages: 41-
50 years, 51-60 years and 61-70 years, but not in patients under 40 years and over 70 years. 49.22% of the patients with GFR < 60 mL/min/1.73 m2 using the aCG equation are included in the same GFR interval in MDRD, and only 8.91% of patients had an estimated GFR ≥ 60
mL/min/1.73 m2 with both formulae. The Pearson correlation coefficient between the aCG and the MDRD equations was good (0.83, p < 0.0001), but the kappa coefficient was 0.48, indicating a low agreement between the 2 formulae. The conclusion of this study is that the Cockroft and MDRD equations cannot be used interchangeably in clinical practice in order to
adjust drug doses.




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