THE BIOCHEMICAL INVESTIGATIONS OF
SOME CLAVICEPS PURPUREA BIOPRODUCTS
AND THEIR IN VITRO CITOSTATIC POTENTIAL
CRAITA ROSU1*, ANA CLARA APROTOSOAIE2, PINCU
ROTINBERG1, DANIELA GHERGHEL1, COSMIN MIHAI1,
ZENOVIA OLTEANU 3, ANCA MIRON 2, STEFANIA SURDU 2,
OANA CIOANCA2, MONICA HANCIANU2
1Institute of Biological Research, Lascar Catargi Street, no. 47, 700107,
Iasi, Romania
2Gr.T.Popa University of Medicine and Pharmacy, Faculty of Pharmacy,
Department of Pharmacognosy, University Street, no. 16, 700115, Iasi,
Romania
3Al. I. Cuza University, Faculty of Biology, Carol I Street, no. 11,
700505, Iasi, Romania
*corresponding author: craita2002@yahoo.com
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Abstract:

The sclerotia of the pyrenomicete Claviceps purpurea (Fr.) Tul. (Hypocreaceae) contains numerous active compounds of which the most known are ergoline alkaloids. In this paper, the mycelian extracts and the corresponding concentrated supernatants, separated from cultures of nine Claviceps purpurea strains, have been biochemically investigated by determination of alkaloids, glucans and proteins. The cytostatic potential of
extracts and concentrated supernatants has been also tested on HeLa tumor cells cultures in the presence of bioactive samples. Generally, the cytostatic potential of these bioactive agents was inversely correlated with the intra - or extracellular ergoline alkaloids content, which seemed not to be the exclusive biochemical substratum for this in vitro pharmacodynamic effect.

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