INVESTIGATION OF ANTIBACTERIAL
ACTIVITY OF FIVE HETEROCYCLIC
COMPOUNDS AGAINST SOME ORAL
STREPTOCOCCAL STRAINS
GABRIELA BANCESCU1*, MANUELA-ANDA RADU-POPESCU21,
ADRIAN BANCESCU3, AMALIA NEAGU4, IRINA NISTOR5,
STEFANIA-FELICIA BARBUCEANU6
1University of Medicine and Pharmacy “Carol Davila”, Faculty of Dental
Medicine, Department of Microbiology, Bucharest, Romania
2University of Medicine and Pharmacy “Carol Davila”, Faculty of
Pharmacy, Department of Microbiology, Bucharest, Romania
3University of Medicine and Pharmacy “Carol Davila”, Faculty of
Medicine, Department of Microbiology-Epidemiology, Bucharest, Romania
4University of Medicine and Pharmacy “Carol Davila”, Faculty of Dental
Medicine, Department of Otorhinolaryngology, Bucharest, Romania
5Emergency Clinical Hospital for Children “Gr. Alexandrescu”, Clinical
Laboratory Department, Bucharest, Romania
6University of Medicine and Pharmacy “Carol Davila”, Faculty of
Pharmacy, Department of Organic Chemistry, Bucharest, Romania
*corresponding author: gabi.bancescu@gmail.com
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Abstract:

The oral streptococci are commensal bacteria, but sometimes may be involved in infections which need antimicrobial treatment. In the general context of an increasing incidence of antibiotic resistant isolates, the investigation of the potential antimicrobial activity of different classes of heterocyclic compounds is considered of great interest. The
aim of the study was to investigate the antimicrobial activity against 64 clinical isolates of oral streptococci belonging to different species of 5 compounds (Ca, Cb, Cc, Cd and Ce) belonging to the class of: 1,2,4-triazole, 1,3,4-thiadiazole or 1,3,4-oxadiazole, which have
been recently reported as newly-synthesized compounds and characterized by spectral and elemental analysis. In the present study, the broth microdilution method was performed to determine the minimum inhibitory concentrations (MIC) of these compounds against the oral streptococci isolates, and afterwards, to determine their minimum bactericidal
concentrations (MBC). The values of the MIC ranged between: 32-256 μg/mL for Ca and Cc, 8-256 μg/mL for Cb, 128-256 μg/mL for Cd and 64-256 μg/mL for Ce. The MBC/MIC ratios were less or equal to 4 in all cases. In conclusion, compared to the other 4 compounds, Cb exhibited the highest degree of growth inhibition against the tested strains and might be subjected to further chemical reactions in order to improve its antimicrobial
activity.

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