SYNTHESIS AND ANTIMICROBIAL SCREENING
OF NOVEL 2, 3 OR 4-[2-ARYL-THIAZOL-YLMETHOXY
(OXO-ETHOXY)]-BENZALDEHYDE
ISONICOTINOYL HYDRAZONE ANALOGS
CRISTINA MOLDOVAN1*, OVIDIU ONIGA1, ROLAND MEDA2,
BRÎNDUŞA TIPERCIUC1, PHILIPPE VERITE 3, ADRIAN PÎRNĂU4,
OVIDIU CRIŞAN1, MARIUS BOJIŢĂ1
1“Iuliu Haţieganu” University of Medicine and Pharmacy, Faculty of
Pharmacy, 41 Victor Babeş Street, RO-400010 Cluj Napoca, Romania
2University of Ouagadougou, Burkina Faso
3University of Medicine and Pharmacy Rouen, Faculty of Pharmacy,
Department of Analytical Chemistry, 22 Boulevard Gambetta, F-76183
Rouen Cedex, France
4National Institute for Research and Development of Isotopic and
Molecular Technologies, RO-400293 Cluj Napoca, Romania
*corresponding author: cris.moldovan@yahoo.com
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Abstract:

We synthesized new aroyl-hydrazones by condensing some derivatives of 4-[2- (4-methyl-2-phenyl-thiazole-5-yl)-2-oxo-ethoxy]-benzaldehyde and 2, 3 or 4-(2-arylthiazol- 4-yl-methoxy)-benzaldehyde, respectively with isonicotinoyl hydrazide, in refluxing acetic acid 50%. The purity of the compounds was demonstrated by thin layer chromatography (TLC). The structures of all new compounds were confirmed by elemental analysis and spectroscopic data (infrared - IR, 1H nuclear magnetic resonance - 1H NMR, mass spectrometry - MS). A screening of the antimicrobial activity was performed. All the compounds were tested in vitro against various Gram-negative and Gram-positive bacteria.
They showed poor to moderate antibacterial activity on Gram-negative strains, compound 6 being the only displaying Gram-positive bacterial growth inhibition.

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