CLINICAL STUDY REGARDING THE
INFLUENCE OF PROTON PUMP INHIBITORS
THERAPY ON THE EVOLUTION OF GASTRIC
AND DUODENAL ULCER, ON ELDERLY
PATIENTS
CRISTIAN BĂLĂLĂU1, FLORIAN POPA1, CAROLINA NEGREI2*
1Sf. Pantelimon University Clinic, Faculty of Medicine, „Carol Davila”
University of Medicine and Pharmacy, Bucharest, Romania
2Toxicology Department, Faculty of Pharmacy, „Carol Davila”
University of Medicine and Pharmacy, Traian Vuia 6, sect. 2, 020956,
Bucharest, Romania
*corresponding author: carol_n2002@hotmail.com
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Abstract:

Advances in medical treatment for gastric ulcer (GU) and duodenal ulcer (DU) have lead to an increase in the number of cases where surgical interventions implied resection and vagotomy. A classic or laparoscopic approach is required by perforated DU, diagnosis responsible for the high percentage of deaths. In this case it is excluded the conservative treatment with proton pump inhibitors and the eradication of the infection with
Helicobacter pylori (HP). Our study presents observations on the treatment of postoperative DU on a group of elderly patients (> 60 years) with associated chronic diseases.
The studied group includes patients hospitalized between 2005 - 2010 in the Department of Surgery, in Sf. Pantelimon, Sf. Ioan, and Colţea Hospitals. Of 186 emergency presentations, 23 were duodenal ulcer relapse, 126 perforated DU and GU 37 were cases of perforated GU. 15-16% were aged> 60 years, mainly males. For cases of duodenal ulcer recurrence in the first aggressive manifestation or recurrent duodenal ulcer, treatment was instituted along with the terapeutical association
regarding the type of diabetes, hypertension, heart failure, cirrhosis.
For this situation, as for the treatment after surgery we considered national and international guidelines, as the consensus in 1996 in Maastricht "European concept in the management of Helicobacter pilory infection" and the 1997 U.S. "American Digestive Health Foundation".

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