STUDY ON THE INFLUENCE OF GELUCIRE
SORT ON THE RELEASE OF ACETAMINOPHEN
FROM ORALLY DISINTEGRATING TABLETS
GRATIELA POPA1*, LACRAMIOARA OCHIUZ1, IULIAN
STOLERIU2, ILEANA COJOCARU1, IULIANA POPOVICI1
1University of Medicine and Pharmacy ”Gr. T. Popa” Faculty of
Pharmacy, 16 Universităţii St., 700115, Iasi, Romania
2 University „Al. I. Cuza” Iasi, Faculty of Mathematics, Carol I Bld,
700506, Iasi, Romania
*corresponding author: gratielapopa@yahoo.com
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Abstract:
The present research continues our previous studies of investigating the
application of polyglycolized glycerides (Gelucire 44/14 and 50/13) as possible binders in wet granulation, with the final aim to prepare orally disintegrating tablets (ODT).
Acetaminophen (APAP) was used as a model drug (300 mg/tablet) and Gelucire sorts were associated with povidone (Kollidon K30) in aqueous solutions in order to improve the properties of tablets and to induce the fast release of acetaminophen. Release of APAP was analyzed at intervals of 1 minute, 5 minutes and 10 minutes, which were set as response variables, by means of a factorial mixed experimental design (2-3-2). The independent variables were set as: % Gelucire, % Kollidon and % Explotab per tablet mass. Both Gelucire types increased the release of APAP, multiple regression equations showing high coefficients for the variable % Gelucire on the release of APAP after 1 minute and 5 minutes. The data fitted better the experimental model for Gelucire 50/13, with better R2
values (> 0.8) compared to Gelucire 44/14.
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