IBUPROFEN PEDIATRIC SUSPENSION
DESIGNED AND OPTIMIZED BY RESPONSE
SURFACE METHODOLOGY
LĂCRĂMIOARA POPA, MIHAELA VIOLETA GHICA*
Physical and Colloidal Chimistry Department, University of Medicine and
Pharmacy "Carol Davila", Faculty of Pharmacy, 6 Traian Vuia, 020956,
Bucharest, Romania
*corresponding author: mihaelaghica@yahoo.com
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Abstract:

Preparation and optimization of an ibuprofen suspension containing
pharmaceutically accepted excipients of pediatric use were performed by a 3-factor, 2-level full statistical design completed with four central point replications. The effects of sucrose (sweetner), Tween 20 (surfactant) and methylcellulose (thickener) on the dispersion properties and on its rheological behaviour (sedimentation index, redispersability degree
and viscosity at 100 rpm) were investigated. A second order model was evaluated by multiple regression and statistically tested for each of the studied formulation factors. The controlled and response variables were correlated using the three-dimensional response surfaces. To determine the validity of the regressional models the optimum formulation was
prepared and its properties determined. The experimental design and response surface methodology proved to be a reliable tool for the formulation and optimization of the named suspension.

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