DIAGNOSIS AND MONITORING OF
MITOCHONDRIAL TOXICITY INDUCED BY
NUCLEOSIDE-ANALOGUE REVERSETRANSCRIPTASE
INHIBITORS IN HIVINFECTED
PATIENTS UNDERGOING
ANTIRETROVIRAL THERAPY
CĂTĂLIN TILIŞCAN1, VICTORIA ARAMĂ1,2, RALUCA
MIHĂILESCU2, ADRIAN STREINU-CERCEL1,2, OANA
ANDREIA COMAN1, DANIELA ION1, ISABEL GHIȚĂ1, ŞTEFAN
SORIN ARAMĂ1*
1University of Medicine and Pharmacy “Carol Davila”, no. 37,
Dionisie Lupu str., 020021 Bucharest, Romania
2„Prof. Dr. Matei Balş” National Institute of Infectious Diseases, no.
1, Dr. Calistrat Grozovici str,. 21106 Bucharest, Romania
*coresponding author: sorinarama@gmail.com
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Abstract:

Highly Active Antiretroviral Therapy (HAART) containing nucleoside reverse transcriptase inhibitors (NRTIs) has been associated with various side effects following mitochondrial toxicity. The most important clincal consequences of mitochondrial DNA (mtDNA) depletion are: lipodystrophy, hepatic toxicity, lactic acidosis, myopathy and polyneuropathy.
In order to prevent the onset of clinical and biological side effects during
NRTIs treatment, different methods have been proposed to assess metabolic toxicity non-invasively and to adequately predict the metabolic risk. These methods have to be harmonized and validated, and there is a need for available commercial tests. Further studies are needed, in order to clarify whether clinicians can prevent mitochondrial toxicity based on the results of mtDNA measurements..

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