THE SOLUBILITY OF OXICAMS, ANTIFUNGAL AZOLES AND SELECTED PSYCHOTROPIC DRUGS IN SIMULATED GASTRO-INTESTINAL FLUIDS AND THE CONSEQUENCES ON THEIR BIOPHARMACEUTICAL CLASSIFICATION
FLAVIAN ŞTEFAN RĂDULESCU1, VICTOR VOICU2, DALIA SIMONA MIRON3*, MIRELA ADRIANA MITU4, ANDREEA LETIŢIA ARSENE5
University of Medicine and Pharmacy „Carol Davila” Bucharest, Faculty of Pharmacy, 6th Traian Vuia street, 020956, Bucharest, Romania
1Department of Drug Industry and Pharmaceutical Biotechnologies,
2Department of Clinical Pharmacology, Toxicology and Psychopharmacology, Faculty of Medicine,
3Department of Pharmaceutical Physics and Informatics,
4Department of Pharmaceutical Technology and Biopharmaceutics,
5Department of Biochemistry.
*corresponding author: dalia_simona_m@yahoo.com
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Abstract:

The role of solubility in four simulated gastro-intestinal fluids in classification of drugs with different biopharmaceutical profiles was investigated. The results underline the different impact of composition variables (mainly pH and concentration of the endogenous tensioactive agent) on the in vivo absorption process, since either dissolution rate or solubility limitation are generally assumed. The most promising candidates for biowaver procedure seem to be the oxicam anti-inflammatory drugs, while safety precaution restricts further extension to psychotropic drugs. The supersaturation process is confirmed for azole antifungals, with major influence of the pH values recorded for ketoconazole.

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