INFLUENCE OF EXTRACTION SOLVENT ON THE ERYTHROMYCIN ETHYLSUCCINATE SEPARATION FROM ORAL SUSPENDABLE POWDER
CĂTĂLINA DANIELA STAN1*, ALINA ŞTEFANACHE2, CRISTINA TUCHILUŞ3, DAN EUGEN DIACONU4, MARIA DRĂGAN1, LENUŢA PROFIRE5
1Department of Drug Industry and Pharmaceutical Biotechnology
2Department of General and Inorganic Chemistry
3Department of Pharmaceutical Microbiology
5Department of Pharmaceutical Chemistry
University of Medicine and Pharmacy “Gr. T. Popa”, Iasi, Faculty of Pharmacy, 16 Universitatii Street, 700115,  Iasi, Romania
4S.C. “Antibiotice” S.A., 1 Valea Lupului Street, 707410, Iasi, Romania
*corresponding author: cdstan@indmed.umfiasi.ro
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Abstract:

The aim of this work was to carry out a separation of erythromycin ethylsuccinate from oral dry suspensions, which don`t correspond at batch quality control. The oral dry suspensions contain erythromycin ethylsuccinate, sugar, sodium saccharin, preservatives, flavours and sodium citrate. We recovered the active substance from the powder mixture, mainly by a solid-liquid extraction process followed by the crystallization of erythromycin ethylsuccinate with a non-solvent. The extraction solvents used in this study were: acetone, ethanol, chloroform and methanol. As non-solvent for crystallization we used distilled water in different volumes. The best results were obtained when acetone was used as extraction solvent and water as non-solvent for crystallization (1:4). The obtained erythromycin ethylsuccinate corresponded from the purity and activity point of view with erythromycin national standard and the method is more convenient from the obtained quantity of erythromycin ethylsuccinate, output and economic points of view. 

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