KETOCONAZOLE IN TOPICAL PHARMACEUTICAL FORMULATIONS.
THE INFLUENCE OF THE RECEPTOR MEDIA ON THE IN VITRO DIFFUSION KINETICS
MIRELA ADRIANA MITU1*, DUMITRU LUPULIASA1, CRISTINA ELENA DINU-PÎRVU2, FLAVIAN ŞTEFAN RĂDULESCU3, DALIA SIMONA MIRON 4, LAVINIA VLAIA5
University of Medicine and Pharmacy „Carol Davila” Bucharest, Faculty of Pharmacy, 6 Traian Vuia street, 020956, Bucharest, Romania
1Department of Pharmaceutical Technology and Biopharmaceutics,
2Department of Physical and Colloidal Chemistry,
3Department of Drug Industry and Pharmaceutical Biotechnologies,
4Department of Pharmaceutical Physics and Informatics,
5University of Medicine and Pharmacy “Victor Babeş”, Faculty of Pharmacy, Department of Pharmaceutical Technology, Timişoara, Romania.
*corresponding author: mirelamitu@clicknet.ro
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Abstract:

The paper describes the evaluation of the in vitro release profiles of ketoconazole from various semisolid and liquid formulations using a vertical diffusion cells system and two types of receptor media, differing by the solubilizing capacity for the active pharmaceutical ingredient (hydro-alcoholic mixture and phosphate buffer pH=5.4, 50 mM). The experimental results indicated the impact of both composition of the receptor media and nature of the pharmaceutical dosage form (the hydrophilic or lipophilic character, the content of tensioactive agents and their solubility in the receptor media, the process of incorporation of the drug into the vehicle) on the diffusion profiles.

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