THE EVALUATION OF THE LIPOPHILIC PROPERTIES OF SOME
THIAZOLYL-OXADIAZOLINES WITH ANTIINFLAMMATORY ACTIVITY

MARIANA PALAGE*, BRÎNDUŞA TIPERCIUC, SMARANDA ONIGA, CĂTĂLIN ARANICIU, DANIELA BENEDEC, OVIDIU ONIGA
Faculty of Pharmacy, „Iuliu Haţieganu” University, 400023, Cluj-Napoca, Romania
*corresponding author: palage14@yahoo.com
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Abstract:

The lipophilicity of 15 new thiazolyl-oxadiazolines was determined, using the principal component analysis (PCA) method. Retention indices were determined by reversed phased thin-layer chromatography (RPTLC). By comparing the results obtained from the lipophilicity data with the anti-inflammatory activity, it was revealed that, for a good anti-inflammatory effect, the compounds need to have medium lipophilicity values. Low or high lipophilicity values are associated with a decrease or abolition of the anti-inflammatory effect.






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