PHARMACOKINETICS OF INTRAVENOUSLY AND ORALLY ADMINISTERED MEMANTINE IN SWINE
LAURIAN VLASE1,*, MARCELA ACHIM1, DANA MUNTEAN1, ADRIAN GAL2, CORNEL CĂTOI2, CONSTANTIN BODOLEA3, SORIN E. LEUCUŢA1
1Department of Pharmaceutical Technology and Biopharmaceutics, University of Medicine and Pharmacy “Iuliu Haţieganu”, Cluj-Napoca, 13 Emil Isac, Romania
2Department of Pathology, University of Agricultural Science and Veterinary Medicine, Cluj-Napoca, 3-5 Calea Manastur, Romania
3Department of Anesthesia and Intensive Therapy, University of Medicine and Pharmacy “Iuliu Haţieganu”, Cluj-Napoca, 13 Emil Isac, Romania
*corresponding author: laurian.vlase@yahoo.com
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Abstract:

A pharmacokinetic study of intravenously and orally administered memantine was run on 12 pigs. The blood samples were collected up to 12 hours after drug administration. The memantine plasma levels were determined using a validated method of liquid chromatography coupled with mass spectrometry detection. Six pharmacokinetic models were screened and the best one describing the absorption and disposition of memantine was chosen. The pharmacokinetics of memantine in pigs is best described by a monocompartmental pharmacokinetic model and 1st order kinetics for both absorption and elimination processes. The memantine has an absolute bioavailability of about 34% and is rapidly cleared from the body, with an elimination rate constant from the central compartment of 0.34±0.06 hr-1 and a mean half-life of 2 hours.

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