OPTIMIZATION OF THE PHARMACEUTICAL PRODUCTS AND PROCESS DESIGN APPLYING TAGUCHI QUALITY ENGINEERING PRINCIPLES

MIHAELA VIOLETA GHICA1*, LĂCRĂMIOARA POPA1, GABRIEL ŞARAMET1, MINODORA LECA2, DUMITRU LUPULIASA1, ŞTEFAN MOISESCU1
1“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, 6 Traian Vuia Str., 020956, Bucharest, Romania
2University of Bucharest, Faculty of Chemistry, 4-12 Regina Elisabeta Blvd., 030018, Bucharest, Romania
*corresponding author: mihaelaghica@yahoo.com
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Abstract:

The main purpose of Taguchi’s methodology is the optimization of pharmaceutical products quality and the design of the processes in order to become insensitive to the noise sources without their elimination. Analyzing the controlled factors (key factors) by selecting their best variation levels the desired responses, robust to the noise factors variation, are obtained with minimum quality losses. Mathematically, the noise impact on the targeted characteristics is evaluated by the signal/noise ratio. It represents an indicator of the performance characteristics of the pharmaceutical products/processes both from the localization and dispersion point of view. Using Taguchi’s technique supplemented with the response surfaces methodology optimal responses are obtained, the robustness of the products/processes is ensured, time is saved, experimental costs are reduced, in one word the global performance is increased.






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