THE INFLUENCE OF SOME TECHNOLOGICAL
PARAMETERS ON TABLET COATING
THICKNESS UNIFORMITY
GABRIEL SARAMET*, DUMITRU LUPULIASA
University of Medicine and Pharmacy “Carol Davila” Bucharest,
Faculty of Pharmacy, Department of Pharmaceutical Technology and
Biopharmacy
*corresponding author: gsaramet@gmail.com
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Abstract:

This paper describes the study of the influence of some formulation factors on tablet coating thickness uniformity. The coating polymer used was Acryl-EZE® from Colorcon. For this purpose, a reduced experimental design, with four variables and three levels was used. The studied variables were: coating dispersion flow rate, coating dispersion concentration, fluid bed temperature and fluid bed airspeed. It was concluded from the results that the most influential factor is the dispersion flow rate, followed by the fluid bed temperature. The experimental data also lead to an optimized formulation, which was tested experimentally and proven to yield a much better coating thickness uniformity.

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