THE OPTIMIZATION OF PROLONGED
RELEASE MATRIX TABLETS WITH
BETAHISTINE DIHYDROCHLORIDE - Part I
RADU CAZACINCU1, DUMITRU LUPULIASA2, ALI HAMZE
MOURAD2
1Ovidius University, Faculty of Pharmacy, Aleea Universităţii nr.1,
Campus, Corp B, Constanta
2Carol Davila University of Medicine and Pharmacy, Faculty of
Pharmacy, Traian Vuia Str. no. 6, Bucharest
*corresponding author: office@magistracc.com
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Abstract:

Hydrophilic matrix tablets with betahistine dihydrochloride and different types of hydroxypropyl methylcellulose (HPMC) with different viscosity degrees were compressed by wet granulation, in order to obtain a prolonged release of the active substance. The effects of the different sorts of HPMC, the pharmaceutical properties (hardness, friability and their influence on in vitro release of the active substance), were studied. The results showed that the percent of HPMC and the degree of viscosity have the highest effect on the release of betahistine dihydrochloride.

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