VALIDATION OF AN ANALYTICAL METHOD
BASED ON HIGH PERFORMANCE LIQUID
CHROMATOGRAPHY FOR DETERMINATION
OF LORATADINE IN PHARMACEUTICAL
PREPARATIONS AND BIOLOGICAL
ENVIRONMENTS
GEORGETA PAVALACHE1, 2*, VASILE DORNEANU1
1Department of Analytical Chemistry, Faculty of Pharmacy, University
Gr. T. Popa, 16 University Street, Iasi,
2Department of Pharmaceutical Chemistry, Faculty of Pharmacy,
Ovidius University, 124 Mamaia Blvd, Constanta
*corresponding author: georgiana_pavalache@yahoo.com
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Abstract:

A high-performance liquid chromatography (HPLC) method for determination of loratadine in pharmaceutical dosage forms and in biological environments was developed by us in a previous study [1]. In the present study, the method was validated in terms of linearity, accuracy, selectivity, precision, limit of detection and limit of quantification.
This method was successfully applied to synthesis process control and determination of loratadine as substance and pharmaceutical preparations.

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