ANTICATARACT ACTIVITY OF
ERDOSTEINE AGAINST EXPERIMENTAL
CATARACTOGENESIS:
AN IN VITRO & IN VIVO STUDY
CHITRA V., MANIMARAN U., SHRINIVAS SHARMA*, DEEPTHI T.
Department of Pharmacology, Sri Ramaswamy Memorial College of
Pharmacy, Sri Ramaswamy Memorial University, Kattankulathur -
603203, Tamil Nadu, India
*corresponding author: shrinivas.sharma29@gmail.com
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Abstract:

Several studies have suggested that antioxidants retard the process of
cataractogenesis by scavenging free oxygen radicals. The present study assessed the efficacy of erdosteine in preventing experimental cataractogenesis in an experimental setting. In the in vitro phase of the study, goat lenses were used and lenses were subjected for photographic evaluation and estimation of the biochemical parameters. In the in vivo phase of the study, nine days old Wistar rat pups were used; on the 16th postpartum day cataract assessment was performed by slit lamp biomicroscope. In the in vitro phase of the study erdosteine significantly restored the lens reduced glutathione (GSH), Ca2+, catalase (CAT), superoxide dismutase (SOD), total protein and water soluble protein levels.
Conversly, erdosteine showed a significant decrease in the malondialdehyde (MDA) content. In the in vivo study, erdostein treatment delayed the development of seleniteinduced cataract in rat pups. Erdosteine protects against experimental cataract development due to its antioxidant properties.

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