MODERN ASPECTS REGARDING THE
MICROBIAL SPOILAGE OF PHARMACEUTICAL
PRODUCTS
ODAY HUSHAM KAMIL1*, DUMITRU LUPULIASA2
1University of Baghdad, Faculty of Pharmacy, Iraq
2University of Medicine and Pharmacy “Carol Davila” Bucharest,
Faculty of Pharmacy, Department of Pharmaceutical Technology
*corresponding author: pharma_oday@yahoo.com
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Abstract:

The aim of this article is to review some of the scientific data dealing with the effect of some environmental factors (water activity, pH and temperature) on microbial spoilage. Contamination of pharmaceutical products with microorganisms could make changes in physico-chemical characteristics as well as the toxicity of pharmaceutical preparations. All the contents of the dosage forms (active ingredients and excipients) are susceptible to microbial contamination and spoilage. Strict measures are required to control microbial contamination in the formulation of pharmaceutical preparations.

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