THE EFFECT OF COPPER SULPHATE ON THE
PRODUCTION OF FLAVONOIDS IN DIGITALIS
LANATA CELL CULTURES
CRISTINA BOTA1*, CONSTANTIN DELIU2
1Department of Drug Industry and Biotechnology, Faculty of Pharmacy,
UMF ”Iuliu Hatieganu”, 4 I. Creanga St., Cluj-Napoca, Romania
2Institute of Biological Researches , Cluj-Napoca, Romania
*corresponding author: laurabota69@yahoo.com
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Abstract:

The paper investigated the effect of abiotic elicitor copper sulphate on the
production of flavonoids in cell cultures of Digitalis lanata. Two cell lines were used (line 11 and line 13C-100) and two types of experiments were performed. In the first type of experiment the highest production of flavonoids was established, for both cell lines, for the strongest elicitor concentration (8μM). In the second type of experiment the maximal flavonoid production was induced for line 11 after 24 hour elicitation (over 10 times more compared with the control, from 0.624mg/g dry weight (d.w.) to 6mg/g d.w.), for the highest elicitor concentration(40μM).

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