HPLC ANALYSIS OF SALICYLIC DERIVATIVES
FROM NATURAL PRODUCTS
ANCA TOIU*, LAURIAN VLASE, ILIOARA ONIGA, DANIELA
BENEDEC, MIRCEA TĂMAŞ
University of Medicine and Pharmacy „Iuliu Hatieganu”, Faculty of
Pharmacy, 12, Ion Creangă Street, 400023, Cluj-Napoca, Romania,
*corresponding author: ancamaria_toiu@yahoo.com
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Abstract:

Salicylate-containing herbs have been used as analgesic and anti-inflammatory remedies from ancient times. In this work we performed a comparative HPLC study of salicylic derivatives in three natural products: Salicis cortex, Populi gemmae and Ulmariae folium. We have identified and measured by a new, easy and fast HPLC method both salicylic acid and salicin, before and after acid hydrolysis, in ethanolic extracts of vegetal products. Ulmariae folium is the richest source of salicylic acid (0.295-0.487%), while Populi gemmae and Salicis cortex contain higher quantities of salicylic alcohol derivatives (0.351-0.366% and respectively 0.199-0.315% salicin).




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